MFG-E8 Plays an Important Role in Attenuating Cerulein-Induced Acute Pancreatitis in Mice

Protective effect of Tribulus terrestris fruit extract on cerulein-induced acute pancreatitis in mice

Objective: Antioxidant, anti-inflammatory, analgesic and antimicrobial activities of Tribulus terrestris (T. terrestris) could be helpful in the treatment of acute pancreatitis; thus, this study was designed to investigate the effects of T. terrestris on cerulein-induced acute pancreatitis in mice. Materials and Methods: Three doses (100, 200 and 400 mg/kg) of T. terrestris hydro-alcoholic extr...

Anti-inflammatory role of cannabidiol and O-1602 in cerulein-induced acute pancreatitis in mice.

OBJECTIVES The anti-inflammatory effects of O-1602 and cannabidiol (CBD), the ligands of G protein-coupled receptor 55 (GPR55), on experimental acute pancreatitis (AP) were investigated. METHODS Acute pancreatitis was induced in C57BL mice by intraperitoneal injection of 50 μg/kg cerulein hourly, with a total of 6 times. Drugs (O-1602, 10 mg/kg, or CBD, 0.5 mg/kg) were given by intraperitonea...

Interleukin-33 plays an important role in sepsis-induced acute lung injury in mice

Evidence has shown that Interleukin-33 (IL-33) plays a key role in the early induction and further amplification of sepsis. However, it remains unknown whether IL-33 has effects on sepsis-induced acute lung injury (ALI) and, if so, whether p38MAPK signaling pathway plays any role in it. This study was designed to insight the role of IL-33 in sepsis-induced ALI, and to discover the relationship ...

preventive effect of cichorium intybus l. two extracts on cerulein-induced acute pancreatitis in mice

objectives: acute pancreatitis is an inflammatory condition of pancreas with sudden onset, high mortality rate and multiple organ failure characteristics. it has been shown that oxygen free radicals have an important role in development of pancreatitis and its complications. antioxidant, anti-inflammatory, anti-hepatotoxicity and gastroprotective properties of cichorium intybus l. suggest that ...

effect of lithium chloride on cerulein-induced acute pancreatitis in mice